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目的研究elaC同系物2(ELAC2)基因变异与中国人群中前列腺癌易感性的关系。方法采用PCR-限制性酶切片段长度多态性的方法 ,在210例前列腺癌患者和230例正常对照者中检测ELAC2基因Ser217Leu和Ala541Thr多态性,采用回归分析研究各基因型与前列腺癌发病风险的关系。结果 Ser217Leu多态性与前列腺癌发生并无明显相关,但是Ala541Thr多态位点对应的Ala/Thr基因型频率在前列腺癌组明显高于正常对照组该基因型出现的频率(10.5%vs.3.0%)(P<0.01),该基因型显著增加了前列腺癌的易感性优势比(OR)=1.52,95%可信区间(CI)=1.78～8.62。而且Thr等位基因在前列腺癌患者中的频率明显大于正常对照组(5.2%vs.1.5%)。结论 ELAC2基因Ala541Thr多态显著增加中国人群前列腺癌的发病风险。
Objective To study the relationship between ELA2 gene polymorphism and the susceptibility to prostate cancer in Chinese population. Methods PCR-restriction fragment length polymorphism (PCR-RFLP) was used to detect the Ser217Leu and Ala541Thr polymorphisms of ELAC2 gene in 210 prostate cancer patients and 230 normal controls. The genotypes and the incidence of prostate cancer were studied by regression analysis The relationship between risk. Results There was no significant correlation between Ser217Leu polymorphism and the incidence of prostate cancer. However, the frequencies of Ala / Thr genotypes corresponding to the Ala541Thr polymorphism were significantly higher in the prostate cancer group than those in the normal control group (10.5% vs.3.0 %) (P <0.01). The genotype significantly increased the susceptibility to prostate cancer odds ratio (OR) = 1.52, 95% confidence interval (CI) = 1.78 ~ 8.62. Moreover, the frequency of Thr allele in prostate cancer patients was significantly higher than that in the normal control group (5.2% vs. 1.5%). Conclusion The Ala541Thr polymorphism of ELAC2 gene significantly increases the risk of prostate cancer in Chinese population.