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目的:口腔颌面部原发性侵袭性纤维瘤十分罕见,本文主要分析口腔颌面部原发性侵袭性纤维瘤的发病情况和临床诊疗措施。方法:回顾性分析我院收治的20例口腔颌面部原发性侵袭性纤维瘤患者的临床及病理特点,采用SPSS 10.0软件包对数据进行t检验。结果:本组20例患者中,男12例,女8例,男女比例3∶2;下颌骨是最常见的发病部位;6例发生癌变,局部复发率高达53%;65%患者的血清碱性磷酸酶含量异常增高(P<0.05),提示病变与颌骨吸收关系密切。结论:口腔颌面部原发性侵袭性纤维瘤具有侵袭性生长及复发率高等特点,治疗以手术切除为主,配合术后放疗,血清碱性磷酸酶水平增高可作为评估骨质吸收的潜在标志物。
OBJECTIVE: Oral and maxillofacial primary invasive fibroma is very rare. This paper mainly analyzes the incidence and clinical diagnosis and treatment of primary invasive fibroma in oral and maxillofacial region. Methods: The clinical and pathological features of 20 patients with primary invasive fibroma in oral and maxillofacial region admitted to our hospital were retrospectively analyzed. The data were analyzed by SPSS 10.0 software package. Results: The group of 20 patients, 12 males and 8 females, the ratio of male to female 3: 2; mandibular is the most common site of disease; 6 cases of cancer, the local recurrence rate as high as 53%; 65% of patients with serum alkali Abnormal increase in the content of phosphatase (P <0.05), suggesting that lesions are closely related to the absorption of the jaw. Conclusions: Oral and maxillofacial primary invasive fibroma have the characteristics of invasive growth and high recurrence rate. Surgical resection is the main treatment. Combined with postoperative radiotherapy, elevated serum alkaline phosphatase level can be used as potential assessment of bone resorption landmark.