论文部分内容阅读
研究25例高血压病(EH)伴有左室肥厚(LVH)者口服培哚普利治疗12周对左室心肌重量(LVMI)与血浆血管紧张素Ⅱ(ATⅡ),醛固酮(ALD)的影响及其相互关系。结果显示,EH患者血浆ATⅡ及ALD浓度明显高于对照组(P<0.001),其LVMI与ATⅡ和ALD正相关(r分别为0.342和0.356,P<0.01),药后LVMI及ATⅡ和ALD水平均显著降低,LVMI下降值与血浆ATⅡ、ALD浓度下降值呈正相关(r分别为0.612和 0.647,P<0.001),提示ATⅡ、ALD是引起EH心肌肥厚重要的体液因素,培哚普利短期治疗可引起LVH逆转。
To study the effects of oral administration of perindopril on left ventricular myocardial mass (LVMI), plasma angiotensin Ⅱ (ATⅡ) and aldosterone (ALD) in 25 hypertensives (EH) with left ventricular hypertrophy (LVH) And their relationship. The results showed that plasma AT Ⅱ and ALD concentrations in patients with EH were significantly higher than those in the control group (P <0.001). LVMI was positively correlated with ATⅡ and ALD (r = 0.342 and 0.356, respectively, P <0.01) (R = 0.612 and 0.647, respectively, P <0.001), suggesting that ATⅡ and ALD are important humoral factors that cause cardiac hypertrophy in EH. Short-term treatment with perindopril Can cause LVH reversal.