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目的探讨本院糖尿病足感染(DFI)患者病原菌及耐药性特点。方法分析2005年1月至2007年12月本院408例DFI患者足创面分离的478株病原菌及其耐药性。结果 DFI以革兰阳性菌为主(54.8%),其次是革兰阴性菌(42.1%)和真菌(3.1%)。3年中金黄色葡萄球菌感染比率呈上升趋势,铜绿假单胞菌呈下降趋势,耐药菌株比率呈逐年下降趋势(P均<0.01);多重耐药株分离率高,并检出42株耐甲氧西林金黄色葡萄球菌。结论 DFI以条件致病菌为主,多重耐药现象普遍存在,对DFI病原菌及其耐药性进行监测,可为DFI防治提供依据。
Objective To investigate the characteristics of pathogenic bacteria and drug resistance in patients with diabetic foot infection (DFI) in our hospital. Methods 478 strains of pathogenic bacteria isolated from the wound surface of 408 patients with DFI in our hospital from January 2005 to December 2007 were analyzed. Results Gram positive bacteria (54.8%) were the main DFIs, followed by Gram negative bacteria (42.1%) and fungi (3.1%). The infection rate of Staphylococcus aureus was on an upward trend in three years, Pseudomonas aeruginosa showed a downward trend, and the rate of drug-resistant strains showed a declining trend year by year (P <0.01). The isolation rate of multiple drug-resistant strains was high and 42 strains were detected Methicillin-resistant Staphylococcus aureus. Conclusion DFI is mainly opportunistic pathogens, and multidrug resistance is widespread. Monitoring DFI pathogens and their drug resistance may provide a basis for DFI prevention and treatment.