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目的 探讨胸腺因子D(TFD)对昆明种小鼠常压耐缺氧作用的影响。方法 对小鼠分别给予TFD灌胃和注射处理,剂量按每日0.625 mg/kg体重。连续处理12天,于第13天在容积为117 ml的测量室中逐只密封小鼠,记录存活时间(min)。结果 TFD腹腔注射和灌胃处理小鼠12天,其常压耐缺氧时间比相应的生理盐水处理的对照组延长,统计处理有显著性意义,P<0.05。同时还发现,TFD灌胃比腹腔注射TFD的常压耐缺氧时间延长(P<0.05)。结论 TFD具有常压耐缺氧作用,可制成口服剂型使用。
Objective To investigate the effect of thymus factor D (TFD) on hypoxia tolerance in Kunming mice. Methods Mice were given intragastric administration of TFD and injection, the daily dose of 0.625 mg / kg body weight. After 12 days of continuous treatment, mice were sealed on the 13th day in a measuring chamber of 117 ml volume and the survival time (min) was recorded. Results The mice treated with TFD intraperitoneally and intragastrically for 12 days had longer duration of hypoxia-tolerance than the corresponding saline-treated control group, with statistical significance (P <0.05). At the same time, it was also found that the time of TFD administration was longer than that of intra-peritoneal injection of TFD (P <0.05). Conclusions TFD has the function of anti-hypoxia and can be used in oral dosage form.