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目的:观察穴区与非穴区对脑功能连接的影响,以探讨腧穴作用特异性的基础.方法:选择21名健康志愿者,随机分为穴位组(12例)和非穴位组(9例),分别针刺受试者双侧足三里和足三里外侧3～4 mm处,采用捻针手法,分别于针刺前、出针后25 min进行功能磁共振扫描,以双侧扣带回作为种子点,分析穴位组和非穴位组脑功能连接情况.结果:穴位组和非穴位组均能产生广泛的脑功能连接,穴位组与非穴位组相比,穴位组在双侧小脑扁桃体、右侧小脑齿状核、双侧小脑悬雍垂、左侧小脑山坡、右侧小脑结节、左侧额下回、双侧颞中回、双侧旁中央小叶、左侧扣带回、右侧颞上回、右侧前扣带回等区域与后扣带回存在功能连接增强,而穴位组双侧额内侧回、右侧额下回与后扣带回的脑功能连接强度较非穴位组减弱.结论:穴位和非穴位所引发脑功能连接的脑区大部分相同,但穴位组在脑内的脑功能连接强度总体上高于非穴位组.“,”Objective To observe the impacts of acupoint and nonacupoint on brain functional connectivity so as to explore the basis of function specificity of acupoint. Methods Twenty-one healthy volunteers were selected and randomized into acupoint group (12 cases) and nonacupoint group (9 cases). Acupuncture was applied to bilateral Zúsānlǐ (足三里 ST 36) and the site 3 to 4 mm lateral to Zúsānlǐ (足三里 ST 36) respectively on the subjects. Rotation needling technique was adopted. MRI was conducted before and 25 min after acupuncture respectively. Bilateral cingular gyrus was taken as seed point to analyze the situations of brain function connectivity in acupoint group and nonacupoint group.Results Brain functional connectivity presented extensively in either acupoint group or nonacupoint group. In comparison between acupoint group and nonacupoint group, in acupoint group, enhanced functional connectivity displayed in bilateral tonsillar, right cerebellar dentate nuclei, bilateral cerebellar uvula, left cerebellar declive, right cerebellar nodule, left inferior frontal gyrus, bilateral middle temporal gyrus, bilateral paracentral lobule, left cingular gyrus, right superior temporal gyrus, right anterior cingular gyrus and other regions, as well as posterior cingular gyrus. But brain connectivity in bilateral medial frontal gyrus, right inferior frontal gyrus, right cingular gyrus was weakened as compared with nonacupoint group. Conclusion The brain regions with functional connectivity induced are mostly same between acupoint and nonacupoint. But, the strength of brain functional connectivity in acupoint group is higher in overall than that in nonacupoint group.