白斑病为鳞状上皮粘膜出现白色或灰白色的斑点或斑块。其境界清晰与否不一,病变开始时,表面呈光滑的灰白色,继而可变为散在的白色斑点状隆起,使患处粘膜表面呈现不同程度的粗糙。按组织病理学检查,可分两类;一类是以上皮细胞增加与显著角化而致肉眼所见白色斑块,早期角质下的棘细胞层有不同程度增厚,晚期则萎缩.一类是粘膜白斑以棘细胞增生为特征,角化较轻,甚至缺如。基底细胞胞核的染色质深染,核分裂相多见。由角化亢进至上皮增生的过渡,可认为是癌变过程 White spot is squamous epithelial mucosa white or gray spots or plaques. The state is not clear or not, the lesion began, the surface was smooth gray, and then into a scattered white spots uplift, mucosal surface of the affected area showed varying degrees of roughness. According to histopathological examination, can be divided into two categories; one is based on the epithelial cells increased and significant keratosis caused by the naked eye to see the white plaque, early keratinocyte layer thickness of thickened in varying degrees, late atrophy. Is the leukoplakia leukoplakia characterized by keratosis lighter, or even missing. Basal cell nuclei deep chromatin, mitotic phase more common. By hyperkeratosis hyperplasia epithelial transition can be considered as cancerous process