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~(99m)Tc(Sn)-甘露醇制剂用于肾显像已有报道,由于肾清除速度不十分快,所以在做动态肾功能和肾小球滤过率研究时不甚满意.作者改用氯化亚铜作还原剂,制成一种新的复合物:~(99m)Tc(Cu)-甘露醇.100mg甘露醇和4mg氯化亚铜溶于2ml水,80℃加热并摇动,水稀释到20ml,取2ml用碳酸氢钠调pH为6～6.5,3～5ml~(99m)TcO_4~-淋洗液与之混合,通过0.22μ的微孔薄膜过滤灭菌.~(99m)Tc(Cu)-甘露醇在大鼠脏器比活性和肾清除:注射后2min,46.8%聚集在肾脏,心和肝脏仅摄取一小部分,其余大部分在血液内;注射后5min,66%在肾组织内,而血液、心和肝脏的总放
~ (99m) Tc (Sn) - mannitol preparation for renal imaging has been reported, because the renal clearance rate is not very fast, so do dynamic renal function and glomerular filtration rate study not satisfied. Using cuprous chloride as a reducing agent, a new complex was prepared: ~ (99m) Tc (Cu) -manitol, 100mg mannitol and 4mg cuprous chloride were dissolved in 2ml water, heated and shaken at 80 ℃, Dilute to 20ml, take 2ml sodium bicarbonate to adjust pH to 6 ~ 6.5, 3 ~ 5ml ~ (99m) TcO_4 ~ -element was mixed with it and filtered through 0.22μ microporous membrane sterilization. ~ (99m) Tc (Cu) - mannitol in rats visceral activity and renal clearance: 2 minutes after injection, 46.8% gathered in the kidneys, heart and liver intake of only a small part of the rest most in the blood; 5min after injection, 66% Kidney tissue, and the total release of blood, heart and liver