呋喃唑酮(痢特灵,Furazolidone,Furoxone)是广泛用于治疗人体细菌性痢疾的有效药物。其物理性状为黄色粉状、无味、难溶于水。据文献报导,它有广谱的抗菌作用,5～10微克/毫升能抑制一般的革兰氏阳性和阴性细菌,20～50微克/毫升有杀菌作用,对抗原虫也有一定的效果。它的作用机理,可能是抑制乙酰辅酶A而干扰了细菌糖代谢的早期阶段。我国鱼类细菌性鱼病流行较广,危害也较大,虽然多年来曾使用多种药物治疗,但因长期使用,产生抗药性(如抗菌素等)或药物保管和使用方法的问题,效果均不甚理想。为此,作者于1976年选择鱼类致病菌之一的粘细菌G_4菌株,用呋喃唑酮进行了室内试管抑菌,杀菌试验和鱼体治疗试验,以及 Furazolidone (Furazolidone, Furoxone) is a potent drug widely used in the treatment of bacterial dysentery in humans. Its physical properties of yellow powder, tasteless, insoluble in water. It has been reported in the literature that it has a broad spectrum of antibacterial activity. 5 to 10 μg / ml inhibits the common Gram-positive and -negative bacteria, 20 to 50 μg / ml for bactericidal activity and also has some effect against protozoal worms. Its mechanism of action may be inhibition of acetyl-CoA and interfere with the early stages of bacterial glucose metabolism. Although the prevalence of bacterial fish disease in our country is relatively wide and the harm is also great, although many kinds of medical treatment have been used over the years, problems such as long-term use, drug resistance (such as antibiotics, etc.) or drug custody and use methods Not ideal. To this end, the authors selected myxobacteria G_4 strain, one of the fish pathogens, in 1976 for in vitro tube bacteriostasis, bactericidal and fish treatment trials with furazolidone, and