目前应用超声心动图彩钯 Doppler 诊断冠心病的方法较多。诸如:室壁运动分析,直接观测冠状动脉口径、冠状动脉血流情况心肌声象图瓣膜返流及心肌灌注声学造影(Myocardia Contrast Echocardiogra-phy 简称 MCE)。但由于 MCE 能直接观察心肌微循环灌注情况,因此,有其不可比拟的优点。1980年 Demaria 首先报道向犬冠状动脉内注入二氧化碳气体或微气泡可使心肌产生超声回声增强效应,并观察到结扎犬单支冠状动脉,其相应室壁造影剂回声缺损(Echo contrast Defect 简称 ECD),而正常冠状动脉相应室壁显示浓密的云雾状回声。之后,许多学者从事 MCE 研究,随着新型造影剂出现及造影方法,分析技术的确定,国外在 MCE 领域已由实验阶段过渡到临床应用,国内目前主要应用于动物实验,临床 At present, there are many methods to diagnose coronary heart disease using echocardiographic color Doppler. Such as: wall motion analysis, direct observation of coronary artery caliber, coronary blood flow myocardial echocardiography valvular regurgitation and myocardial perfusion imaging (Myocardia Contrast Echocardiogra-MIE for short). However, because MCE can directly observe the perfusion of myocardial microcirculation, it has its incomparable advantages. In 1980, Demaria first reported that the injection of carbon dioxide gas or microbubbles into the canine coronary artery can produce enhanced echogenic effects of the myocardium and observed the ligation of canine coronary arteries, the corresponding Echo contrast Defect (ECD) , Whereas the normal coronary arteries show a dense, cloud-like echo. Since then, many scholars have been engaged in MCE research. With the appearance of new contrast agents and the determination of imaging methods and analytical techniques, foreign countries have transitioned from experimental phase to clinical application in MCE field. At present, they are mainly used in animal experiments and clinics