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正常及用6-羟基多巴胺(6-OHDA)损毁黑质的28只大白鼠分成3组,用高效液相色谱-电化学检测器(high performance liquid chromatography-electrochemical detection,HPLC-EC)分别测定其两侧尾壳核中多巴胺(DA)及其代谢产物高香草酸(HVA)、3,4-二羟基苯乙酸(DOPAC)的含量。单侧损毁组损毁侧尾壳核中DA、HVA/DA、DOPAC/DA 3项指标,分别相当于健侧的22.27％、420.00％、199.75％,显示损毁侧纹状体内幸存的DA神经末梢有代偿性的递质释放增强效应。单侧损毁组损毁侧与双侧损毁组两侧尾壳核间、单侧损毁组健侧与正常对照组两侧尾壳核间,上述各指标差异无显著性,提示损毁侧尾壳核内代偿性的多巴胺释放增强效应,很可能是同侧黑质-纹状体系统的机能代偿所致。
Twenty-eight normal and 6-hydroxydopamine (6-OHDA) -based substantia nigra were divided into 3 groups, and were determined respectively by high performance liquid chromatography-electrochemical detection (HPLC-EC) The contents of dopamine (DA) and its metabolites homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the caudate putamen. The indexes of DA, HVA / DA and DOPAC / DA in the damaged caudate putamen of unilateral damage group were respectively 22.27%, 420.00% and 199.75% of the uninjured ones, which showed that there were DA nerve endings surviving in the damaged lateral striatum Compensatory neurotransmitter release enhancing effect. There was no significant difference in the above indexes between the caudate putamen on both sides of unilateral rupture group and the caudatus nucleus on both sides of damaged rupture group and contralateral putamen nucleus on both sides of unilateral rupture group and normal control group, Compensatory dopamine release enhancing effect, probably due to ipsilateral substantia nigra - striatum system due to functional compensation.