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运用高效液相色谱法，研究了静脉注射时，螨胺磷在大鼠体内的代谢动力学特征、组织分布及排泄途径，并初步分离了胆汁中的代谢产物。结果显示：螨胺磷在体内全身分布，并有周室富集，消除较快，在１０ｍｇ／ｋｇ静脉注射呈二室模型，ｔ１／２α为３．４０ｍｉｎ，ｔ１／２β为５９．０３ｍｉｎ，全身清除率Ｃｌ（ｓ）０．０１８ｍｌ·ｍｉｎ－１；螨胺磷主要分布于血流量大的器官及脂肪组织；螨胺磷在体内不稳定，能被肝脏代谢转化成极性更高的化合物后经由胆汁排出，该成分可在同样的色谱条件下被分离，峰保留时间４．２５ｍｉｎ；粪尿中均未检出原药
Using high performance liquid chromatography (HPLC), the pharmacokinetics, tissue distribution and excretion pathway of mite in rats after intravenous injection were studied. The metabolites of bile were initially separated. The results showed that there was a systemic distribution of mite, and the enrichment of peritoneal space was rapid. The two-compartment model was established at the dose of 10 mg / kg. The t1 / 2α was 3.40 min and the t1 / 2β was 59.03 min. Clearance rate Cl (s) 0.018ml · min-1; mite is mainly distributed in organs and adipose tissues with large blood flow; mite is not stable in vivo and can be metabolized by the liver into more polar compounds Through the bile excretion, the composition can be separated under the same chromatographic conditions, peak retention time 4.25min; were not detected in the original drug excreta