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目的观察法舒地尔治疗急性脑梗死的临床疗效和安全性。方法将符合标准的病人127例,分为治疗组68例和对照组59例,基础治疗均为三七总皂苷400mg加入氯化钠注射液250mL,iv,gtt,qd;治疗组加用法舒地尔注射液30mg加入氯化钠注射液100mL,iv,gtt,bid,疗程14d。治疗前和治疗后对2组病人进行神经功能缺损程度(NIS)和日常生活活动功能(ADL)评分,并进行疗效比较。结果治疗组总有效率94%,对照组81%,疗效差别有显著意义(P<0.05)。2组病人治疗前与治疗后NIS和ADL比较,同时进行2组间NIS和ADL比较,都有显著差异(P<0.05或P<0.01)。结论急性脑梗死发病应用法舒地尔可有效改善病人神经功能缺损和日常生活能力,且无严重不良反应。
Objective To observe the clinical efficacy and safety of Fasudil in the treatment of acute cerebral infarction. Methods A total of 127 eligible patients were divided into treatment group (n = 68) and control group (n = 59). The basal therapy included 250 mg Panax notoginseng saponin plus sodium chloride injection (iv, gtt, qd) Seoul injection 30mg sodium chloride injection 100mL, iv, gtt, bid, treatment 14d. Before treatment and after treatment, two groups of patients with neurological deficit (NIS) and activities of daily living function (ADL) score, and efficacy comparison. Results The total effective rate was 94% in the treatment group and 81% in the control group, the difference was significant (P <0.05). There were significant differences between the two groups in NIS and ADL before treatment and after treatment, and between NIS and ADL in both groups (P <0.05 or P <0.01). Conclusion The application of fasudil in the onset of acute cerebral infarction can effectively improve the patient’s neurological deficit and daily living ability without serious adverse reactions.