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目的 :研究功能性消化不良病人胃排空功能的异常与症状之间的关系及西沙比利疗效。方法 :对 36例功能性消化不良病人 4种症状进行分级 ,并行胃排空检查 ,分别与健康人对照组 12例比较 ,并与西沙比利 5mg ,po ,tid治疗后自身对照比较。结果 :半排时间固体实验组治疗前为 5 9min±s 10min ,健康人对照组为 5 0min± 11min(P <0 .0 5 ) ,治疗后为 4 9min± 9min(P <0 .0 5 ) ;液体半排时间分别为 13min± 4min ,15min± 6min (P >0 .0 5 ) ,治疗后为 13min± 3min与治疗前比较P >0 .0 5。腹胀、腹痛、恶心、呕吐与固体胃排空延迟的回归系数分别为 0 .381,0 .5 43,0 .178,0 .4 63。结论 :功能性消化不良病人固体胃排空延迟 ,且可被西沙比利纠正 ,腹胀、腹痛、呕吐是固体胃排空延迟的危险因素
Objective: To study the relationship between abnormal gastric emptying function and symptoms in patients with functional dyspepsia and the efficacy of cisapride. Methods: Four kinds of symptoms of 36 patients with functional dyspepsia were graded and compared with gastric emptying examination. Twelve cases were compared with healthy control group and compared with self-control of cisapride 5 mg, po, tid. Results: The half-time solid experiment group was 59 min ± s 10 min before treatment, the control group was 50 min ± 11 min (P <0.05), the mean time was 49 min ± 9 min after treatment (P <0.05) ; Liquid half-time were 13min ± 4min, 15min ± 6min (P> 0.05), 13min ± 3min after treatment compared with before treatment P> 0.05. The regression coefficients of abdominal distension, abdominal pain, nausea, vomiting, and delayed gastric emptying were 0.381,0.5,46 .178,0. CONCLUSIONS: Functional dyspepsia patients have delayed gastric emptying and can be corrected with cisapride. Bloating, abdominal pain and vomiting are risk factors for delayed gastric emptying