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目的探究淋巴细胞主动免疫治疗封闭抗体缺乏所致反复流产的临床效果。方法 200例封闭抗体缺乏所致反复流产患者为研究对象,随机分为研究组及对照组,各100例。研究组采用淋巴细胞主动免疫方法治疗,对照组采用常规方法治疗。比较两组妊娠成功率及研究组治疗后封闭抗体阳性与阴性妊娠情况。结果研究组妊娠80例、流产20例,妊娠成功率为80.00%;对照组妊娠48例、流产52例,妊娠成功率为48.00%;研究组妊娠成功率高于对照组,差异具有统计学意义(χ~2=22.222,P<0.05)。研究组治疗后封闭抗体阳性患者妊娠成功60例、再次流产8例,妊娠成功率为88.24%;阴性患者妊娠成功20例、再次流产12例,妊娠成功率为62.50%;阳性患者妊娠成功率高于阴性患者,差异具有统计学意义(χ~2=9.007,P<0.05)。结论淋巴细胞主动免疫治疗封闭抗体缺乏所致反复流产可靠,效果显著。
Objective To investigate the clinical effect of active immunotherapy of lymphocytes on the abortion caused by lack of blocking antibody. Methods 200 patients with recurrent abortion due to lack of blocking antibody were randomly divided into study group and control group, with 100 cases each. The study group was treated with active immunization of lymphocytes, and the control group was treated by conventional methods. The success rate of pregnancy was compared between two groups and the positive and negative antibodies of blocking antibody in the study group after treatment were compared. Results The study group 80 cases of pregnancy, 20 cases of abortion, pregnancy success rate was 80.00%; control group 48 cases of pregnancy, abortion 52 cases, the pregnancy success rate was 48.00%; study group pregnancy success rate was higher than the control group, the difference was statistically significant (χ ~ 2 = 22.222, P <0.05). The study group of patients with positive antibody-blocking pregnancy after the successful 60 cases of abortion in 8 cases, the pregnancy success rate was 88.24%; negative pregnancy success in 20 cases, 12 cases of abortion again, pregnancy success rate was 62.50%; positive pregnancy rate was high In negative patients, the difference was statistically significant (χ ~ 2 = 9.007, P <0.05). Conclusion Active immune therapy of lymphocytes caused by lack of blocking antibodies, repeated abortion, reliable, significant effect.