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Two newly identified tumor necrosis factor (TNF) family cytokines,B cell activation factor from the TNFfamily (BAFF) and a proliferation-inducing ligand (APRIL),have recently been shown to enhance thematuration and survival of peripheral B cells.However,whether BAFF and APRIL are expressed in the bonemarrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear.In the present study,we have detected the abundant expression of BAFF and APRIL transcripts in BMnon-lymphoid cells.Low levels of BAFF and APRIL mRNA are also found in developing B cells.Furthermore,we have determined the expression patterns of BAFF receptors during B lymphopoiesis.In cultures,bothrecombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF cansuppress apoptosis of immature B cells.These findings suggest that BAFF and APRIL,in addition to their wellestablished role in regulating peripheral B cell growth,can modulate the survival of developing B cells in theBM.Cellular & Molecular Immunology.2004;1(6):447-453.
Two newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. and APRIL are expressed in the bonemarrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear. the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BMnon-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Future, we have determined the expression patterns of BAFF receptors during B lymphopoiesis. cultures, both are recombinant BAFF and APRIL significantly promote the survival of precursor B cells but BAFF cansuppress apoptosis of immature B cells These findings suggest that BAFF and APRIL, in addition to their wellestablished role in regulating peripheral B cell growth, can modulate the survival o f developing B cells in the BM. Cellular & Molecular Immunology. 2004; 1 (6): 447-453.