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药物从给药到生效可分为相继发生的药物动力学过程和药效学过程。前者涉及到许多因素,例如:吸收,转运、代谢、排泄等,后者指药物与作用部位的受体、酶等生物大分子间的反应,即所谓药物的内在活性等。药物的疏水参数logP(即药物在脂水两相中分配系数的对数值)是表征这两个过程的重要参数之一。测定药物的logP 值不仅可以估计其体内的吸收、转运等情况,而且能推测其活性大小(通过QSAR 方程)。本文建立的分光光度法是测定药物logP 的一种实用方法。
Drugs from administration to effectiveness can be divided into successive pharmacokinetic and pharmacodynamic processes. The former involves many factors, such as: absorption, transport, metabolism, excretion, etc., the latter refers to the drug and the site of action receptors, enzymes and other biological macromolecules between the reaction, the so-called drug intrinsic activity. The hydrophobic parameter logP (that is, the logarithm of the distribution coefficient of the drug in the lipid-water phase) is one of the important parameters to characterize the two processes. Measuring the logP value of a drug can not only estimate its absorption, transport and so on, but also predict its activity (through the QSAR equation). The spectrophotometry established in this paper is a practical method to determine the drug logP.