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目的:旨在研究用MRI T2*WI检测自发性脑出血后含铁病灶的演变过程。方法:大鼠脑内注射不同体积的自体动脉血(A组10μL;B组50μL;C组100μL)。各组术后第1、3、7、14和30天行脑部MRI T2WI和T2*WI扫描,记录图像特征。由Image J软件进行图像分析。结果:大鼠脑内注射自体血后,MRI T2*WI图像较T2WI明显清晰;A、B组大鼠术后7和14 d含铁病灶体积T2*WI较T2WI所测得的体积更大(P<0.05);C组大鼠术后第7、14和30天,T2*WI比较T2WI测得的体积也更大(P<0.05)。结论:在自发性脑出血后含铁病灶的检测中,MRI T2*WI较MRI T2WI更为清晰和敏感。
OBJECTIVE: To investigate the evolution of iron-bearing lesions after spontaneous intracerebral hemorrhage detected by MRI T2 * WI. METHODS: Different volumes of autologous arterial blood were injected into the brain of rats (group A: 10μL; group B: 50μL; group C: 100μL). Brain MRI T2WI and T2 * WI were performed on the 1st, 3rd, 7th, 14th and 30th day after operation in each group to record the image features. Image J software for image analysis. Results: Compared with T2WI, T2WI images of T2WI in T2WI group at 7 and 14 days after operation in rats in group A and group B were larger than those in T2WI P <0.05). On the 7th, 14th and 30th day after operation, the volume of T2WI in T2 * WI group was also larger than that in T2WI group (P <0.05). Conclusion: MRI T2 * WI is more clear and sensitive than MRI T2WI in the detection of iron-containing lesions after spontaneous intracerebral hemorrhage.