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目的探讨生活指导配合药物治疗妊娠期高血压患者对其血清hsp70、瘦素及尿酸水平的影响。方法将220例妊娠高血压患者随机分为研究组和对照组各110例。对照组予硫酸镁和硝苯地平治疗,研究组在对照组基础上给予生活指导。比较2组患者血清水平hsp70、瘦素及尿酸水平的变化。结果治疗前2组血清hsp70、瘦素及UA水平差异无统计学意义(P>0.05)。治疗后2组hsp70、瘦素和UA水平均低于治疗前,且研究组瘦素、UA水平低于对照组,差异有统计学意义(P<0.05)。2组治疗后hsp70水平差异无统计学意义(P>0.05)。结论生活辅导配合硫酸镁、硝苯地平治疗妊娠期高血压患者较单独使用药物治疗具有更好的疗效,值得临床推广应用。
Objective To investigate the effect of life guidance and drug treatment on the serum hsp70, leptin and uric acid levels in patients with gestational hypertension. Methods 220 cases of pregnancy-induced hypertension were randomly divided into study group and control group of 110 cases. The control group was treated with magnesium sulfate and nifedipine, and the study group was given life guidance on the basis of the control group. The serum levels of hsp70, leptin and uric acid in the two groups were compared. Results There was no significant difference in serum hsp70, leptin and UA levels between the two groups before treatment (P> 0.05). After treatment, the levels of hsp70, leptin and UA in both groups were lower than those before treatment, and the levels of leptin and UA in the study group were lower than those in the control group (P <0.05). There was no significant difference in hsp70 level between the two groups after treatment (P> 0.05). Conclusion Life counseling with magnesium sulfate, nifedipine in patients with gestational hypertension patients with drug treatment alone has a better effect, it is worthy of clinical application.