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目的比较食管腔内微波加温合并体外放射治疗食管癌与单纯放射治疗的疗效。方法对 2 15例食管癌进行前瞻性分组研究。食管腔内加温合并体外照射 (R +H)组 10 4例 ,单纯体外照射 (RT)组 111例 ,R +H组外照射DT4 0Gy ,腔内加温 1～ 2次 /周 ,4 5min/次 ,要求肿瘤表面温度 >4 3℃。RT组外照射DT6 0Gy ,2Gy/次 ,5次 /周。结果近期疗效显示R +H组完全缓解率达 4 4 .8% ,RT组为 2 4 .3% ,有显著性差异 (P <0 .0 5 )。 1、5、10年生存率R +H组分别为 77.1%、2 2 .9%和 14 .3% ,RT组为 6 0 .4 %、13.5 %和 5 .4 %。结论食管腔内加温合并体外放射治疗可以提高食管癌的局部控制率 ,近期疗效和远期疗效均高于对照组。局部控制率的高低与加温的次数无明显关系 ,关键在于每次的加温质量 (T90 的高低 )。
Objective To compare the curative effect of intra-esophageal microwave heating combined with external beam radiotherapy for esophageal cancer and radiotherapy alone. Methods 215 cases of esophageal cancer were prospectively divided into groups. In 104 cases of esophageal lumen exacerbation combined with external irradiation (R + H), 111 cases were treated by external irradiation (RT) alone, 5min / time, requiring the tumor surface temperature> 43 ℃. RT group outside the DT6 0Gy, 2Gy / times, 5 times / week. Results The recent curative effects showed a complete remission rate of 44.8% in R + H group and 24.3% in RT group, with significant difference (P <0.05). The 1-, 5-, 10-year survival rates were 77.1%, 22.9% and 14.3% in the R + H group and 60.4%, 13.5% and 5.4% in the RT group, respectively. Conclusion The combination of esophageal lumen heating and external beam radiotherapy can improve the local control rate of esophageal cancer, the short-term curative effect and long-term curative effect are higher than the control group. The level of local control rate and the number of heating no significant relationship, the key is that each heating quality (T90 level).