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儿童肥胖症患病率的迅速增加迫切需要提出一级预防的有效策略。有证据表明早期的营养规划决定了后期的肥胖风险。在调整了生物学和社会人口学等混杂因素的基础上,统计表明母乳喂养可以降低学龄期儿童肥胖的优势比(大约20%～25%),我们认为母乳喂养的保护效应部分是因为它可以减少婴儿期体重增加,这同基质的摄取不同有一定的联系。普通的喂养方式每kg体重蛋白的摄取比母乳喂养大约高55%～80%。我们猜测早期超过生理需要的高蛋白摄入促进了婴儿的体重增加并且增加了日后的肥胖风险。(“早期蛋白假设”)。通过对欧洲的5个地区的1150个婴儿进行随机双盲干预试验,欧洲儿童肥胖计划验证了这个假设。非母乳喂养婴儿随机的摄取较高或较低的蛋白质量并随访到学龄期。如果可以确定婴儿的喂养习惯对日后肥胖风险的影响,那么对于有效的进行预防干预将是非常有利的,而且对于儿童和成年人的健康也是非常有意义的。
The rapid increase in the prevalence of childhood obesity urgently requires an effective strategy for primary prevention. There is evidence that early nutritional planning determines the risk of obesity in the later stages. Based on a combination of confounding factors such as biology and socio-demography, statistics show that breastfeeding can reduce the odds ratio (about 20% -25%) of childhood obesity in school-age children and we consider the protective effect of breastfeeding in part because it can Reduce weight gain in infancy, which is different with the substrate intake have some contact. The average feeding method per kg of body weight protein intake than breastfeeding about 55% ~ 80%. We hypothesize that early high protein intake exceeding physiological needs promotes infant weight gain and increases the risk of obesity in the future. ( “Early protein hypothesis ”). The European Children’s Fat Program validates this hypothesis by conducting a randomized double-blind intervention trial of 1,150 infants in five European regions. Non-breastfed infants randomized to higher or lower protein intake and followed up to school age. If the impact of infant feeding practices on the future risk of obesity can be determined, it would be very beneficial for effective prevention interventions and also very meaningful for the health of children and adults.