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目的探讨睡眠剥夺（ＳＤ）条件下应用咖啡因对人的工效及情绪情感状态的影响。方法８名受试者自身前后对照，在６：００至次日８：００的２６ｈ的睡眠剥夺过程中于凌晨１：００随机服用安慰剂（淀粉１０ｍｇ）或咖啡因（２００ｍｇ），采用随机双盲给药。并在７：００、１２：００、１６：００、２０：００、２４：００、２：００、４：００、６：００、８：００各完成一套测试。测试项目包括：①听觉Ｏｄｄ－ｂａｌ模式单任务反应时（ＲＴ１）；②手控跟踪加听觉Ｏｄｄｂａｌ双任务跟踪误差（ＥＲ）及反应时（ＲＴ２）；③情绪情感量表（ＰＯＭＳ）等。结果①用药后１ｈ，ＥＲ在咖啡因组与安慰剂组间有显著性差异（Ｐ＜０．０５）；用药后３ｈ，ＲＴ２在咖啡因组与安慰剂组间有显著性差异（Ｐ＜０．０１），用药后５ｈ，ＲＴ１及ＥＲ在咖啡因组与安慰剂组间有显著性差异（分别为Ｐ＜０．０１和Ｐ＜０．０５）。②用药后１ｈ，ＰＯＭＳ的紧张－焦虑（Ｔ）、忧郁－沮丧（Ｄ）、有力－好动（Ｖ）、疲惫－惰性（Ｆ）及困惑－迷茫（Ｃ）的评分在咖啡因组与安慰剂组间有显著性差异（Ｐ＜０．０５）；用药后３ｈ，有力－好动（Ｖ）和疲惫－惰性（Ｆ）两项指标的评分在咖啡因组与安慰剂组之间有显著性差异（Ｐ?
Objective To explore the effects of caffeine on ergonomics and emotional state under sleep deprivation (SD). METHODS: Eight subjects were randomized to either placebo (starch 10 mg) or caffeine (200 mg) at random at 1:00 am during a 26 h sleep deprivation from 6:00 am to 8:00 am on the following day. Blind administration. A set of tests will be completed at 7:00, 12:00, 16:00, 20:00, 24:00, 2:00, 4:00, 6:00 and 8:00. Test items include: ① auditory Odd-bal mode single-task response time (RT1); ② manual tracking plus Oddbal dual task tracking error (ER) and reaction time (RT2); emotional emotional scale (POMS) and so on. Results ① At 1h after treatment, ER was significantly different between caffeine group and placebo group (P <0.05); RT2 was significantly different between caffeine group and placebo group at 3h .01). RT1 and ER were significantly different between caffeine group and placebo group at 5h after treatment (P <0.01 and P <0.05, respectively). ② At 1h after treatment, the scores of POMS-anxiety (T), depression-depression (D), potency-activeness (V), fatigue-inertia (F) and puzzled- There was a significant difference between the two groups (P <0.05). At 3h after treatment, the scores of force-good motion (V) and fatigue-inertness (F) were significantly different between caffeine group and placebo group Sex differences (P?