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目的探讨血清中葡萄糖6磷酸异构酶(GPI)阳性的中国汉族类风湿关节炎(RA)的临床特点。方法用酶联免疫吸收法(ELISA)在283例中国汉族RA患者中对GPI进行了测定,并分析GPI与RA临床表现和其他辅助检查结果之间的关系。结果 GPI在中国汉族RA患者中的阳性率为83.04%,与GPI阴性的RA患者相比,GPI阳性的RA患者的起病年龄较轻[(39±15)岁vs(51±18)岁,P<0.05)],28处关节疾病活动度积分(DAS28)较高[(3.772±0.281)分vs(2.783±0.564)分,P<0.05)]。结论 GPI在中国汉族RA患者的阳性率较高,有助于RA的筛查。血清中GPI阳性的RA患者的起病年龄相对较轻,病情活动性较高。
Objective To investigate the clinical features of Chinese Han rheumatoid arthritis (RA) with positive serum glucose 6 phosphate isomerase (GPI). Methods The GPI was measured in 283 Chinese Han patients with RA by enzyme-linked immunosorbent assay (ELISA), and the relationship between the clinical manifestations of GPI and RA and other auxiliary examinations was analyzed. Results The positive rate of GPI in Chinese Han RA patients was 83.04%. Compared with GPI-negative RA patients, the GPI-positive RA patients had a younger age of onset [(39 ± 15) vs (51 ± 18) years, P <0.05). The 28 points of joint disease activity score (DAS28) were higher (3.772 ± 0.281) vs (2.783 ± 0.564) points, P <0.05). Conclusions The positive rate of GPI in Chinese Han patients with RA is high, which is helpful for the screening of RA. Serum GPI-positive RA patients with relatively mild age of onset, the disease activity is higher.