胰岛素样生长因子(IGFs)系统通过内分泌、自分泌和旁分泌机制调节细胞的生长、分化、凋亡和转化,对胚胎的生长和出生后的发育具有关键作用,并且可促进成年人组织的维持和修复。研究证实,IGF系统参与增生性玻璃体视网膜病变(PVR)的发生发展,并且被认为是重要的蛋白系统。就IGF系统在PVR疾病中的研究进展进行综述。 Insulin-like growth factor (IGFs) systems regulate the growth, differentiation, apoptosis and transformation of cells through endocrine, autocrine and paracrine mechanisms and are crucial for embryonic growth and postnatal development and may promote the maintenance of adult tissues And repair. Studies confirm that the IGF system is involved in the development of proliferative vitreoretinopathy (PVR) and is considered as an important protein system. The research progress of IGF system in PVR diseases are reviewed.