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标准急性毒性实验设计需用大量动物,但并不能得到有价值的全身毒性资料。作者介绍的急性毒性实验设计方法,可以用少量的动物得到更多的有用资料,最大地发挥人员和设备的效率,此外还对许多毒性试验理论的基本概念进行了评价,设计方法为单只动物试探(Singleanimal probe):作者认为,LD_(50)不应仅作为毒性的一个数据,它是对群体动物毒性估计的一个指标,只有在和
Standard acute toxicity experimental design requires a large number of animals, but does not get valuable systemic toxicity information. The author introduces an acute toxicity experimental design method that can be used to obtain more useful data with a small amount of animals to maximize the efficiency of personnel and equipment. In addition, the basic concepts of many toxicity test theories are also evaluated, and the design method is single animals Singleanimal probe: The authors believe LD_ (50) should not only be used as a measure of toxicity but as an indicator of toxicity to groups of animals,