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目的研究六味地黄汤水提醇溶部位对2型糖尿病大鼠胰岛及肾脏的影响。方法采用高糖、高脂饲料喂养4周后,再行腹腔注射小剂量链脲佐菌素(STZ)且空腹血糖(FBG)≥16.7 mmol/L的大鼠建立2型糖尿病动物模型,将其随机分为空白组、模型组、罗格列酮组和六味地黄汤水提醇溶部位组,观察给药1个月后大鼠空腹血糖(FBG)和大鼠胰岛、肾脏组织的形态结构。结果六味地黄汤水提醇溶部位能降低2型糖尿病大鼠FBG值(P<0.01),对其受损的胰岛及肾脏有修复作用。结论六味地黄汤水提醇溶部位能够修复2型糖尿病大鼠的胰岛及肾脏,胰岛及肾脏是具干预2型糖尿病作用的靶位之一。
Objective To study the effect of Liuwei Dihuang decoction on the islets and kidneys of type 2 diabetic rats. Methods The model of type 2 diabetic rats was established by intraperitoneal injection of low dose streptozotocin (STZ) and fasting blood glucose (FBG) ≥16.7 mmol / L for 4 weeks after feeding with high glucose and high fat diet. The rats were randomly divided into blank group, model group, rosiglitazone group and Liuweidihuang decoction group. The fasting blood glucose (FBG) and the islet and kidney morphology of rats were observed after 1 month. Results The aqueous extract of Liuweidihuang Decoction could reduce the FBG value of type 2 diabetic rats (P <0.01) and repair the damaged islets and kidneys. Conclusion Liuweidihuang decoction can repair islets and kidneys of type 2 diabetic rats by isoluminolysis. Islets and kidneys are one of the targets of intervention for type 2 diabetes mellitus.