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目的:探讨纳洛酮、苯巴比妥对重度窒息新生儿内皮素(ET)、丙二醛(MDA)含量及存活率影响。方法:重度窒息新生儿53例,分A组:纳洛酮、苯巴比妥治疗组25例;B组:苯巴比妥治疗组28例。C组:非窒息对照组31例。在第1天用药前0 h及纳洛酮和(或)苯巴比妥治疗后1 d、7 d分别取血,测定血浆ET、MDA含量。比较A组、B组存活率。结果:A、B两组1d血浆ET、MDA水平较0h明显降低,A组较B组ET、MDA水平下降更为显著,两组在同一时间点ET、MDA相比差异分别有统计学意义(P<0．01),而7 d三组之间相比无统计学意义(P>0．05)。存活率相比无统计学差异(P>0．05)。结论:纳洛酮、苯巴比妥联用可明显降低ET及MDA水平,而具有脑保护作用。
Objective: To investigate the effects of naloxone and phenobarbital on endothelin (ET), malondialdehyde (MDA) content and survival rate in neonates with severe asphyxia. Methods: Fifty-three newborns with severe asphyxia were divided into group A (naloxone) and phenobarbital (n = 25). Group B: phenobarbital (n = 28). C group: non-asphyxia control group of 31 cases. On the first day before treatment 0 h and naloxone and (or) phenobarbital treatment 1 d, 7 d were taken blood, plasma ET, MDA levels. Compare group A, group B survival rate. Results: The levels of plasma ET and MDA in group A and group B were significantly lower than those in group 0h. The levels of ET and MDA in group A were significantly lower than those in group B. The differences in ET and MDA between the two groups at the same time point were statistically significant P <0.01), while there was no significant difference between the three groups on the 7th day (P> 0.05). No significant difference in survival rate (P> 0.05). Conclusion: The combination of naloxone and phenobarbital can significantly reduce the level of ET and MDA, and has a protective effect on the brain.