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目的:探讨不同促排卵方案在接受体外受精-胚胎移植(IVF-ET)的卵巢低反应患者中的应用价值。方法:对87例卵巢低反应患者采用不同方案进行IVF/ICSI-ET共200个周期的临床资料进行回顾性分析,其中短方案者50个周期(A组),拮抗剂方案者39个周期(B组),微刺激方案者93个周期(C组),自然周期方案者18个周期(D组)。比较分析各组的促排卵结局。结果:4组间周期取消率无统计学差异,hCG注射日LH水平A组低于其他3组,E2水平高于其他3组,与C、D组比有统计学差异(P<0.05),优势卵泡数及平均获卵数D组低于其他3组,而正常受精率高于其他3组,与A、B组比有统计学差异(P<0.05),hCG注射日内膜厚度、P值、MⅡ卵率、可利用胚胎率、临床妊娠率C组临床妊娠率略高,但各组间差异均无统计学意义(P>0.05)。结论:对卵巢低反应患者微刺激方案在IVF-ET促排卵中相对其他方案有更好的临床效果。
Objective: To explore the value of different ovulation induction programs in patients with ovarian hyporesponse who underwent in vitro fertilization-embryo transfer (IVF-ET). Methods: The clinical data of 87 patients with low ovarian response in 200 cycles of IVF / ICSI-ET were retrospectively analyzed. Among them, 50 cycles of short-term program (group A) and 39 cycles of antagonist program Group B), 93 cycles of micro-stimulus (Group C) and 18 cycles of natural cycle (Group D). Comparative analysis of ovulation induction in each group. Results: There was no significant difference in the cancellation rate among the four groups. The level of LH on day of hCG injection was lower in group A than in other three groups, and the level of E2 was higher than the other three groups (P <0.05) The number of dominant follicles and the average number of oocytes retrieved in group D were lower than the other three groups, while the normal fertilization rate was higher than the other three groups (P <0.05), the thickness of intima of hCG injection day, P The clinical pregnancy rate in group C was slightly higher, but there was no significant difference between groups (P> 0.05). Conclusion: The micro-stimulation regimen in patients with low ovarian response has a better clinical effect than other regimens in IVF-ET ovulation induction.