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目的:观察低分子量肝素对脑梗死的临床疗效和血液流变学的影响。方法:随机选取32例经临床确诊的脑梗死患者,给予低分子量肝素和脑保护剂治疗,在治疗前后检测血液流变学特性,并进行临床疗效观察。结果:经低分子量肝素治疗后,患者全血高切黏度(P=0.0008)、全血低切黏度(P=0.0009)、血浆黏度(P=0.0008)、红细胞压积(P=0.0351)、血沉(P=0.0093)、全血高切还原黏度(P=0.0007)、全血低切还原黏度(P=0.0008)、红细胞聚集指数(P=0.0075)均显著降低,治疗总有效率达87.5%。结论:低分子量肝素可以有效地改善脑梗死患者的血液高凝状态,疗效显著。
Objective: To observe the effect of low molecular weight heparin on the clinical curative effect and hemorheology of cerebral infarction. Methods: 32 randomly selected patients with clinically diagnosed cerebral infarction were treated with low molecular weight heparin and brain protectant. The hemorheological properties were measured before and after treatment, and the clinical curative effect was observed. Results: After low molecular weight heparin treatment, the patients had high blood viscosity (P = 0.0008), low blood viscosity (P = 0.0009), plasma viscosity (P = 0.0008), hematocrit (P = 0.0351) (P = 0.0093), whole blood high shear reduction viscosity (P = 0.0007), whole blood low cut reduction viscosity (P = 0.0008) and erythrocyte aggregation index (P = 0.0075) were significantly decreased. The total effective rate was 87.5%. Conclusion: Low molecular weight heparin can effectively improve blood hypercoagulability in patients with cerebral infarction.