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目的探讨SOX13抗体(SOX13-Ab)与2型糖尿病(T2DM)患者颈动脉内中膜厚度(IMT)的关系。方法选取248例谷氨酸脱羧酶抗体(GAD-Ab)阴性的T2DM患者,检测SOX13-Ab指数等,彩色B超测量受试者颈动脉IMT及可视斑块范围。探讨SOX13-Ab指数与IMT增厚、斑块发生的相互关系。结果 (1)IMT与发病年龄呈显著正相关,与SOX13-Ab指数呈显著负相关(P均<0.05)。(2)随SOX13 Ab指数升高,IMT、内膜增厚(IMT>0.9mm)风险性及斑块阳性率渐降;SOX13-Ab最低五分位组IMT显著高于其他各分位;内膜增厚风险性显著高于4~(th)1/5、5~(th)1/5分位组,斑块阳性率显著高于4~(th)1/5分位组(P均<0.05)。(3)随斑块严重程度的增加,SOX13-Ab指数递减;0级组患者SOX13-Ab指数显著高于2级组(P<0.05)。结论 SOX13-Ab指数与T2DM患者IMT具有良好负相关性,可望成为判断T2DM患者发生IMT增厚及动脉粥样硬化危险性的新指标。
Objective To investigate the relationship between carotid artery intima-media thickness (SOT) of SOX13 antibody (SOX13-Ab) and type 2 diabetes mellitus (T2DM). Methods 248 cases of T2DM patients with negative GAD-Ab antibody were selected to detect the index of SOX13-Ab. The color B-ultrasound was used to measure the carotid IMT and visual plaque range. To investigate the relationship between SOX13-Ab index and IMT thickened and plaque occurrence. Results (1) There was a significant positive correlation between IMT and age of onset, and a significant negative correlation with SOX13-Ab index (all P <0.05). (2) With the increase of SOX13 Ab index, the risk of IMT and intimal thickening (IMT> 0.9mm) and the positive rate of plaque decreased gradually; the IMT of SOX13-Ab in the lowest quintile was significantly higher than that in other quantiles The risk of membranous thickening was significantly higher than that in 4 th (th) 1/5 and 5 th (th) 1/5 scale, and the positive rate of plaque was significantly higher than that in 4 th (th) 1/5 scale (P <0.05). (3) SOX13-Ab index decreased as the severity of plaque increased; SOX13-Ab index of grade 0 group was significantly higher than that of grade 2 group (P <0.05). Conclusion There is a negative correlation between SOX13-Ab index and IMT in T2DM patients, which is expected to become a new index for judging the risk of IMT thickening and atherosclerosis in T2DM patients.