S Zorb adsorptive desulfurization technology is of great significance on the production of clean gasoline in China, but the formation of Zn_2SiO_4 during the operation in sorbents would bring forth negative impacts on the desulfurization performance and the stability of the processing unit. By using the in-situ TPO, XRD, and IR techniques to study the mechanism of Zn_2SiO_4 formation under operating conditions, it was found that the coexistence of acid and hydrothermal conditions could accelerate the formation of Zn_2SiO_4. Moreover, the study of Zn_2SiO_4 inhibition method indicated that the decrease of oxygen concentration in regeneration gas would inhibit the rate of Zn_2SiO_4 formation, and the regeneration of Zn S would take place in a mild regeneration condition. S Zorb adsorptive desulfurization technology is great significance on the production of clean gasoline in China, but the formation of Zn_2SiO_4 during the operation in sorbents would bring forth negative impacts on the desulfurization performance and the stability of the processing unit. By using the in- situ TPO, XRD, and IR techniques to study the mechanism of Zn_2SiO_4 formation under operating conditions, it was found that the coexistence of acid and hydrothermal conditions could accelerate the formation of Zn_2SiO_4. Moreover, the study of Zn_2SiO_4 inhibition method indicated that the decrease of oxygen concentration in regeneration gas would inhibit the rate of Zn_2SiO_4 formation, and the regeneration of Zn S would take place in a mild regeneration condition.