视黄酸(retinoic acid,RA)又名维甲酸是维生素A的活性衍生物,是小分子质量、脂溶性信号分子,通过与其细胞内的受体α(retinoic acid receptorα,RARα)结合发挥生物学功能,在调节生物各种进程如细胞分化、调亡、胚胎发育、再生和视力发育中发挥重要作用。研究表明在很多疾病如炎症性肠病(IBD)、肿瘤等患者体内视黄酸含量减少,给予视黄酸制剂能有效的抑制疾病的进程。目前视黄酸在机体免疫调节中发挥的作用尚不完全明确,有人认为其通过对Th1/Th2和Th17/Treg平衡的调节而发挥在机体抑制炎症的作用,而在肿瘤方面的作用机制则较为复杂。本文将对视黄酸在机体免疫中发挥的作用做一综述。 Retinoic acid (RA), also known as retinoic acid, is an active derivative of vitamin A and is a small-molecule, fat-soluble signaling molecule that plays a role in biology by binding to its intracellular receptor alpha (retinoic acid receptor alpha, RAR alpha) Function, play an important role in regulating biological processes such as cell differentiation, apoptosis, embryonic development, reproduction and visual development. Studies have shown that in many diseases such as inflammatory bowel disease (IBD), tumors and other patients reduced retinol content, given retinoic acid preparations can effectively inhibit the progress of the disease. At present, the role of retinoic acid in the immune regulation of the body is not yet completely clear. Some people think that it exerts an inhibitory effect on inflammation in the body through the regulation of the balance of Th1 / Th2 and Th17 / Treg, while the mechanism of action in the tumor is relatively complex. This article will review the role of retinoic acid in immune system.