论文部分内容阅读
目的探讨慢性腹泻患者肠黏膜形态和通透性的变化。方法对33例慢性腹泻患者和30名健康志愿者行结肠镜检查,并在镜下取回肠末端和回盲部黏膜各3块,光镜下观察肠黏膜的组织结构,同时测定尿中的乳果糖/甘露醇(L/M)比值,以评价肠黏膜屏障功能。结果慢性腹泻患者光镜下可见回肠末端有绒毛顶端上皮细胞水肿、脱落,但与健康志愿者差异无统计学意义(P>0.05);回盲部可见被覆上皮细胞明显水肿、脱落和破溃,甚至被覆上皮细胞成片完全脱落,与健康志愿者比较差异有统计学意义(P<0.05)。慢性腹泻患者和健康志愿者尿L/M比值差异无统计学意义(P>0.05)。结论慢性腹泻患者可能存在结肠黏膜屏障损害。
Objective To investigate the changes of intestinal mucosa morphology and permeability in patients with chronic diarrhea. Methods 33 cases of chronic diarrhea patients and 30 healthy volunteers underwent colonoscopy, and the end of the gut and the ileocecal mucosa were taken three times. The histological changes of intestinal mucosa were observed under light microscope. Lactulose / mannitol (L / M) ratio to evaluate intestinal mucosal barrier function. Results In patients with chronic diarrhea, there was edema and shedding of epithelial cells on the top of the ileum under light microscope. However, there was no significant difference between healthy volunteers and chronic diarrhea patients (P> 0.05). In the ileocecal region, the edema, detachment, Even covered epithelial cells into pieces completely off, compared with healthy volunteers, the difference was statistically significant (P <0.05). There was no significant difference in urinary L / M ratio between chronic diarrhea patients and healthy volunteers (P> 0.05). Conclusion There may be colonic mucosal barrier damage in patients with chronic diarrhea.