论文部分内容阅读
目的:观察乙肝抗纤汤辅助治疗乙肝后肝纤维化的疗效。方法:选取2013年2月至2015年4月在青海省第四人民医院治疗的乙肝后肝纤维化患者136例,随机分为观察组(n=73)和对照组(n=63),对照组给予常规保肝、抗病毒药物治疗,观察组在对照组治疗的基础上给予乙肝抗纤汤治疗,观察两组患者治疗前后血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、层粘蛋白(LN)水平及肝功能变化和肝脏组织病理。结果:治疗后观察组血清AST、ALT、HA、LN、Ⅳ-C水平及纤维化和炎症计分显著低于对照组(P<0.05),两组患者治疗期间未发现严重不良反应。结论:乙肝抗纤汤辅助治疗乙肝后肝纤维化具有良好疗效,能有效促进肝功能恢复和抗肝纤维化。
Objective: To observe the curative effect of Hepatitis B and Anti-fibrosis Decoction on posthepatitic liver fibrosis. Methods: A total of 136 patients with posthepatitic cirrhosis of hepatitis B treated in Qinghai Fourth People’s Hospital from February 2013 to April 2015 were randomly divided into observation group (n = 73) and control group (n = 63) The patients in the observation group were given hepatitis B and anti-fibangolive therapy on the basis of the treatment of the control group. The levels of serum hyaluronic acid (HA), type Ⅳ collagen (Ⅳ-C) Laminin (LN) levels and liver function changes and liver histopathology. Results: Serum levels of AST, ALT, HA, LN, Ⅳ-C and fibrosis and inflammation in the observation group were significantly lower than those in the control group (P <0.05). No serious adverse reactions were found in the two groups during treatment. Conclusion: Hepatitis B and anti-fibangolic decoction can effectively treat liver fibrosis after hepatitis B, and can effectively promote the recovery of liver function and anti-hepatic fibrosis.