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目的观察腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗中晚期胃癌的疗效。方法中晚期胃癌患者125例分为两组:试验组58例,采用腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗;对照组67例,实施腹腔镜胃癌根治术治疗。比较两组疗效和相关的不良反应发生情况。结果两组在手术时间和手术、化疗相关并发症等方面无统计学差异(P>0.05)。随访8~25个月:试验组2年无病生存时间长于对照组[(25.0±3.8)个月vs.(17.0±1.5)个月](P<0.05),2年复发率低于对照组(39.7%vs.52.2%)(P<0.05),2年生存率高于对照组(72.4%vs.55.2%)(P<0.05)。结论腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗中晚期胃癌可行,是一种有效且并发症少的腹腔化疗方法。
Objective To observe the curative effect of laparoscopic radical gastrectomy combined with fluorouracil extended release in the treatment of advanced gastric cancer. Methods One hundred and fifty-five patients with advanced gastric cancer were divided into two groups: 58 in the trial group. The patients in the trial group were treated with laparoscopic radical gastrectomy combined with fluorouracil sustained-release agent. The control group was treated with laparoscopic radical gastrectomy. The curative effect and related adverse reactions of the two groups were compared. Results There was no significant difference between the two groups in the operation time, complications related to surgery and chemotherapy (P> 0.05). The follow-up of 8 to 25 months: The 2-year disease-free survival time in the experimental group was longer than that in the control group [(25.0 ± 3.8) months vs. (17.0 ± 1.5) months] (P <0.05) (39.7% vs.52.2%) (P <0.05). The 2-year survival rate was higher than that of the control group (72.4% vs.55.2%, P <0.05). Conclusions Laparoscopic radical gastrectomy with implantable fluorouracil sustained-release agent is feasible for the treatment of advanced gastric cancer. It is an effective and less-complicated intraperitoneal chemotherapy.