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以单十二烷基磷酸酯为模板剂制备了Sm3+和Fe3+共掺杂的兼具磁性和荧光特性的纺锤形介孔纳米羟基磷灰石。利用XRD、SEM、TEM、VSM、PL及氮气吸附-脱附曲线等手段对产物进行了表征与研究。掺杂的Sm3+和Fe3+以固溶和镶嵌氧化物纳米粒子2种形式存在于羟基磷灰石基体中。煅烧前后,Sm3+和Fe3+共掺杂的羟基磷灰石试样均具有良好的超顺磁性。煅烧使试样的比饱和磁化强度从13.45(A·m2)·kg-1增加至19.51(A·m2)·kg-1。煅烧后,Sm3+和Fe3+共掺杂羟基磷灰石呈纳米纺锤体形貌,长200~350 nm,直径50~100 nm。其中分布有大量的双孔介孔,孔径分别为3.64和9.01 nm。大量双孔分布的介孔使产物具有大的比表面积和高的孔体积比,分别为153.52 m2/g和0.3286 cm3/g。产物具有生物靶向性、生物标识性及高的载药容量,在药物载体中具有大的应用潜力。
Spindle mesoporous nano-hydroxyapatite with both magnetic and fluorescent properties co-doped with Sm3 + and Fe3 + was prepared using monododecyl phosphate as template. The products were characterized and studied by means of XRD, SEM, TEM, VSM, PL and nitrogen adsorption-desorption curves. The doped Sm3 + and Fe3 + are present in the hydroxyapatite matrix as both solid solution and embedded oxide nanoparticles. Before and after calcination, Sm3 + and Fe3 + co-doped hydroxyapatite samples have good superparamagnetism. Calcination increased the specific saturation magnetization of the sample from 13.45 (A · m2) · kg-1 to 19.51 (A · m2) · kg-1. After calcination, Sm3 + and Fe3 + co-doped hydroxyapatite nano spindle morphology, length 200 ~ 350 nm, diameter 50 ~ 100 nm. There are a large number of double-pore mesopores distributed in them with pore sizes of 3.64 and 9.01 nm, respectively. A large number of mesopores distributed in two pores make the product have large specific surface area and high pore volume ratio of 153.52 m2 / g and 0.3286 cm3 / g, respectively. The product has biological targeting, biomarker and high drug loading capacity, which has great potential in drug carriers.