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目的 采用三维有限元法分析骨水泥注入量对椎体后凸成形术(PKP)后患椎相邻椎体生物力学的影响.方法 经PKP治疗的骨质疏松性椎体压缩性骨折(OVCF)患者69例,根据骨水泥注入量分为低剂量(>2.0 mL且0.05).末次随访未发现相邻椎体再发骨折.在低压力(中立位)时,患椎下位椎体的应力较术前增加约22%,上位椎体的应力增加约15%.在中压力(正常活动)、高压力(突然摔倒)时,高剂量组患椎上、下位椎体的应力较低压力时均明显增加,差异有统计学意义(P0.05).结论 PKP术后可引起患椎上、下相邻节段生物力学的改变,相邻椎体所受的应力随着轴向负荷和骨水泥注入量的增加呈增加趋势.“,”Objective To explore the biomechanical effects of different amount of bone cement on adjacent vertebral bodies after percutaneous kyphoplasty(PKP). Methods Totally 69 patients with osteoporotic vertebral compression fractures(OVCF) who underwent PKP were included and divided into 3 groups according to the amount of bone cement:low dose(>2.0 mL and 0.05). No adjacent vertebral body fracture was found in the final follow-up. At low pressure(neutral position),the pressure in the lower vertebra increased by about 22% compared with pre-operation;and upper vertebral body stress increasedby about 15%. At medium pressure(normal activities) and high pressure(suddenly falls down),stress of the vertebral body in high dose group were significantly increased than neutral position with a statistical difference(P 0.05). Conclusion PKP changes the biomechanical distribution on adjacent vertebrae. With the increases of axial pressure and the amount of bone cement,the biomechanical effect has the increasing trend.