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目的:观察自拟中药补肾方对肾性骨营养不良(ROD)大鼠肾功能的影响。方法:采用5/6肾切除法建立肾功能衰竭大鼠模型,随机分为中药补肾方高剂量组、低剂量组、阳性对照组(骨化三醇)、模型组、假手术组(n=10)。灌胃给药12周,各组取血清测定生化指标,取胫骨测定骨密度,并于光镜下观察病理改变。结果:中药补肾方能够影响ROD大鼠血清钙和碱性磷酸酶水平,改善肾功能,减轻骨组织病理改变,通过整体作用延缓ROD的发生和发展。结论:中药补肾方对ROD大鼠有防治作用。
Objective: To observe the effect of self-made Bushen Recipe on renal function in renal osteodystrophy (ROD) rats. Methods: A rat model of renal failure was established by 5/6 nephrectomy. The rats were randomly divided into high dose of Bushen Fang, low dose, positive control group (calcitriol), model group, sham operation group (n = 10). The rats were given gavage for 12 weeks. The biochemical indexes were determined by serum in each group. The bone mineral density was measured by tibia, and pathological changes were observed under light microscope. Results: Bushen Recipe can affect the levels of serum calcium and alkaline phosphatase, improve renal function, alleviate the pathological changes of bone tissue, delay the occurrence and development of ROD. Conclusion: Bushen Recipe has preventive and therapeutic effects on ROD rats.