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目的研究慢性丙型肝炎患者血清中白介素-18(interleukin-18,IL-18)的表达情况,探讨IL-18在慢性丙型肝炎发病中的作用及可能的临床意义。方法酶联免疫吸附法(ELISA)检测20例正常人,42例慢性丙型肝炎患者血清中IL-18水平。结果慢性丙型肝炎患者中谷丙转氨酶升高组血清IL-1 8表达明显高于健康对照组[(422.8±11.2)pg/mlvs(104.1±10.9)pg/ml,P<0.05],谷丙转氨酶正常组血清IL-18表达也高于健康对照组[(219.8±20.6)pg/mlvs(104.1±10.9)pg/ml,P<0.05]。且慢性丙型肝炎患者血清IL-18表达与谷丙转氨酶、谷草转氨酶均具有正相关性(r1=0.701,P<0.05;r2=0.769,P<0.05)。结论慢性丙型肝炎患者中IL-18表达增高,且与谷丙、谷草转氨酶水平有关。IL-18可能在慢性丙型肝炎的发生发展、转归和预后中具有一定临床指导意义。
Objective To investigate the expression of interleukin-18 (IL-18) in serum of patients with chronic hepatitis C and to explore the role of IL-18 in the pathogenesis of chronic hepatitis C and its possible clinical significance. Methods Serum levels of IL-18 in 20 normal subjects and 42 chronic hepatitis C patients were detected by enzyme-linked immunosorbent assay (ELISA). Results The serum level of IL-18 in patients with chronic hepatitis C was significantly higher than that in healthy controls [(422.8 ± 11.2) pg / ml vs (104.1 ± 10.9) pg / ml, P <0.05] The expression of IL-18 in normal group was also higher than that in healthy control [(219.8 ± 20.6) pg / ml vs (104.1 ± 10.9) pg / ml, P <0.05]. The serum level of IL-18 in patients with chronic hepatitis C was positively correlated with alanine aminotransferase and aspartate aminotransferase (r1 = 0.701, P <0.05; r2 = 0.769, P <0.05). Conclusion The expression of IL-18 is increased in patients with chronic hepatitis C, and is related to the level of alanine and aspartate aminotransferase. IL-18 may have some clinical significance in the development, prognosis and prognosis of chronic hepatitis C.