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1996年 Linnen 从美国慢性肝炎患者血清中分离出庚型肝炎病毒(HGV),属黄病毒科,为单股正链 RNA 病毒,基因全长9392个核苷酸碱基,编码2 873个氨基酸,5′末端有458个非编码碱基,3′端有315个非编码碱基。病毒基因编码包括 E_1、E_2、NS_2、NS_3、NS_4、NS_5等区。C 区较短,仅79个氨基酸咀同年Simons等在西非分离出的GBV-(’型病毒的核苷酸及编码氨基酸序列和HGV同源性很高,所以近年国际上多用 HGV/GBV C 表示。GBV-A 及 GBV-B 为从一例肝炎病人(GB)感染的狷毛猴血清中分离出,在人群中可测出抗体,但末分离出病毒 RNA。根椐病毒种系学研究,GBV-A 和 HGV/GBV-C 相近,GBV-B 和 HCV 相近,认为 HCV 可能系从 GBV-B 演化而来。HGV 的基因结构和 HCV 相似。HGV 可能也存在亚型,Mukaide 等收集16个国家146份 HGV 5′非编码区进行系列测定并进行种系分析,认为可以分为3个亚型;(1)GBV-C 可见于非洲、北美、亚洲及欧洲;(2)新组:主要见于亚洲及欧洲;(3)HGV,主要见于欧洲、亚洲及北美,并认为 HGV 的演化较 GBV-C 为迟。
1996 Linnen Hepatitis G virus (HGV) isolated from the serum of the United States patients with chronic hepatitis, is a Flaviviridae family, is a single-stranded positive-sense RNA virus, the gene is 9392 nucleotides in length encoding 2 873 amino acids, There are 458 non-coding bases at the 5 ’end and 315 non-coding bases at the 3’ end. The virus gene coding includes E_1, E_2, NS_2, NS_3, NS_4, NS_5 and other regions. C region is short, only 79 amino acids Tsui same year Simons and other isolated in West Africa GBV- (’virus nucleotide and coding amino acid sequence and HGV homology is high, so in recent years, the international community with HGV / GBV C GBV-A and GBV-B were isolated from one monkey infected with hepatitis B (GB), and antibodies were detected in the population, but viral RNA was not isolated at the end. -A is similar to HGV / GBV-C, GBV-B is similar to HCV, and HCV may be derived from GBV-B. The genetic structure of HGV is similar to that of HCV.HGV may also exist in subtypes, and Mukaide et al. Collected 16 countries 146 HGV 5 ’non-coding regions were sequenced and phylogenetically analyzed and considered to be subdivided into 3 subtypes; (1) GBV-C was found in Africa, North America, Asia and Europe; (2) New group: Asia and Europe; (3) HGV, mainly found in Europe, Asia and North America, and believes that the evolution of HGV is later than that of GBV-C.