目的 :通过对凝胶剂经皮渗透速率的比较 ,优化二乙胺水杨酸凝胶剂处方。方法 :用 3种不同浓度异丙醇作促渗剂 ,制备凝胶。采用Franz扩散池进行小鼠离体皮肤体外渗透试验。结果 :药物经皮渗透符合零级动力学过程 ,不同浓度异丙醇促渗效果为 :15 %异丙醇 >10 %异丙醇 >5 %异丙醇。结论 :经皮渗透试验筛选处方是可行的。 OBJECTIVE: To optimize the formulation of diethylamine salicylate gels by comparing the transdermal permeation rates of gels. Methods: Three different concentrations of isopropanol as penetration enhancers were used to prepare gels. Franz diffusion cells were used to in vitro skin penetration test in mice. Results: The transdermal drug permeation was in accordance with the zero-order kinetics. The permeation promoting effect of isopropanol with different concentrations was 15% isopropanol> 10% isopropanol> 5% isopropanol. Conclusion: The transdermal penetration test screening prescription is feasible.