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目的 探讨应用人工肝支持系统(ALSS)治疗重型肝炎的疗效及减少ALSS不良反应的方法。方法 设观察组48例,对照组32例,两组在护肝综合治疗的基础上,观察组同时给予ALSS治疗。观察不同病期治愈好转率、总有效率,平均住院天数和主要实验室检查指标及ALSS治疗的不良反应。结果 观察组重型肝炎早、中、晚期治愈好转率分别为100％、80％、28.57％,总有效率72.29％,对照分别为:66.67％、54.55％、10.00％,总有效率46.87％,临床治愈病例平均住院时间:观察组为(21.25±12.69)天,对照组为(52.36±17.27)天,两组均有显著性差异(P<0.001)。观察组ALSS治疗232人次,发生不良反应20人次,不良反应发生率8.62％。结论 ALSS为重型肝炎的治疗提供了较为安全有效的手段,ALSS对重型肝炎早、中期疗效较好,减少肝素用量,严格无菌操作及预防性用药,可减少不良反应。
Objective To investigate the efficacy of artificial liver support system (ALSS) in the treatment of severe hepatitis and to reduce the adverse reactions of ALSS. Methods 48 cases of observation group, 32 cases of control group, two groups in the comprehensive treatment of liver based on the observation group were given ALSS treatment. Observe the healing rate of different stages of disease, the total effective rate, the average number of days of hospitalization and the main laboratory test indicators and ALSS treatment of adverse reactions. Results The improvement rates of early, middle and late treatment of severe hepatitis in observation group were 100%, 80% and 28.57%, respectively. The total effective rate was 72.29%, the control was 66.67%, 54.55% and 10.00% respectively, the total effective rate was 46.87% The average length of hospital stay in the cured cases was (21.25 ± 12.69) days in the observation group and (52.36 ± 17.27) days in the control group, with significant differences between the two groups (P <0.001). In the observation group, 232 patients were treated with ALSS, 20 were adverse reactions, and the incidence of adverse reactions was 8.62%. Conclusions ALSS provides a safe and effective method for the treatment of severe hepatitis. ALSS has a good effect in the early and middle stages of severe hepatitis, reduces the amount of heparin, strictly asepsis and preventive medication, and can reduce adverse reactions.