用粗针穿刺活检,冰冻切片、组织化学技术,对17例地方性甲状腺肿、15例毒性甲状腺肿,13例桥本氏甲状腺炎组织的过氧化物酶、单胺氧化酶、琥珀酸脱氢酶的组织化学改变进行研究。结果发现地方性甲状腺肿的胶质结节的过氧化物酶的活性低于正常。实质结节的三种酶的活性均比胶质结节的高。毒性甲状腺肿的三种酶的活性均比地方性甲状腺肿和桥本氏甲状腺炎高。桥本氏甲状腺炎,过氧化物酶比正常低。 Thirty-seven cases of endemic goiter, 15 cases of toxic goiter and 13 cases of Hashimoto’s thyroiditis tissues were peroxidase, monoamine oxidase and succinate dehydrogenase tissue by needle biopsy, frozen sections and histochemical techniques Chemical changes were studied. The results showed that endemic goiter glial nodular peroxidase activity below normal. The activity of the three enzymes of the nodules are higher than the glial nodules. Toxic goiter activity of the three enzymes are higher than endemic goiter and Hashimoto’s thyroiditis. Hashimoto’s thyroiditis, peroxidase lower than normal.