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本文用吗啡依赖猴作对比,对恒河猴海洛因依赖形成的时间、累计剂量、催促实验戒断反应的量 -效、时 -效变化及自然戒断反应出现的时 -效关系等进行了研究。结果表明 :海洛因sc恒河猴,起始剂量为2.5mg·kg-1 ,tid ,每2d递增1.25mg·kg-1,日剂量达11.25mg·kg-1 后,改为每日递增1.25mg·kg-1,日剂量达到20mg·kg-1 时,维持该剂量到用药时间为3mon。给药d5,当海洛因累计剂量为17.5mg·kg-1 时,催促实验中,猴出现明显的戒断症状,以后随给药剂量的增加,戒断反应呈显著的量 -效、时 -效变化,反应强度在给药头10d内增加最快,以后呈缓慢上升的趋势。注射满3mon,突然停药,可出现明显的戒断症状,其时 -效关系与吗啡组基本一致。与吗啡组相比,在依赖形成初期,海洛因具有形成依赖时间短,用药量少,戒断反应程度严重,戒断症状稍有不同,有兴奋表现等特点。海洛因组Emax=100分,ED50 =20.9mg·kg-1;吗啡组Emax=104.2分,ED50 =80.7mg·kg-1,二者的等效剂量比为1∶3.9。自然戒断实验中,二组均达最大反应强度,且戒断反应程度基本相近。
In this paper, compared with morphine-dependent monkeys, the time, cumulative dose of heroin dependence, the quantity-response, time-response and the time-effect relationship of spontaneous abstinence response in experimental rhesus monkeys . The results showed that: heroin sc in monkeys, the initial dose of 2.5mg · kg-1, tid, every 2d increments 1.25mg · kg-1, the daily dose of 11.25mg · kg-1, changed daily increased 1.25mg · Kg-1, the daily dose of 20mg · kg-1, the dose to maintain the time of 3mon. Administration of d5, when the cumulative heroin dose of 17.5mg · kg-1, urging the experiment, the monkey showed obvious withdrawal symptoms, with the increase of dose, the withdrawal was significant dose-effect, time-effectiveness Changes, the intensity of reaction in the first 10d to increase the fastest, after a slow upward trend. Injection 3mon, a sudden withdrawal, there may be significant withdrawal symptoms, the time-effect relationship with the morphine group basically the same. Compared with the morphine group, in the early stage of dependence formation, heroin has the characteristics of short dependence, less dosage, severe withdrawal response, slightly different withdrawal symptoms, and excited performance. Emax was 100 and ED50 was 20.9 mg · kg-1 in heroin group, while Emax was 104.2 and ED50 was 80.7 mg · kg-1 in morphine group respectively. The equivalent dose ratio was 1: 3.9. Natural withdrawal test, the two groups reached the maximum response intensity, and the degree of withdrawal response were similar.