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研究目的是利用声辐射力脉冲弹性成像技术(Acoustic Radiation Force Impulse,ARFI)评估大鼠肝脏的脂肪变性程度。实验通过对大鼠喂养不同时间高脂食物从而诱导成肝脏脂肪变性不同阶段,进而利用ARFI技术离体测量大鼠肝脏的剪切波速度值(Shear Wave Velocity,SWV)。研究结果显示,对照组[(2.25±0.52)m/s)]与脂肪变性组[(2.83±0.37)m/s]之间存在着显著性差异(P<0.05),而脂肪变性不同阶段之间差异却不明显。早期炎症等级与SWV值之间没有显著性相关。因此,ARFI弹性成像技术可以有效地区分大鼠肝脏正常组和脂肪变性组,但是对不同脂肪变性程度之间无法做出有效区分。同时,轻微的炎症活动并不影响ARFI测量。
The purpose of the study was to assess the extent of steatosis in rat livers using Acoustic Radiation Force Impulse (ARFI). Rats were fed different times of high-fat diet to induce hepatic steatosis in different stages, and then the shear wave velocity (SWV) of rat liver was measured ex vivo using ARFI technique. The results showed that there was a significant difference (P <0.05) between the control group [(2.25 ± 0.52) m / s) and steatosis group (2.83 ± 0.37 m / s) The difference is not obvious. There was no significant correlation between early grade of inflammation and SWV value. Therefore, the ARFI elastography technique can effectively differentiate between the normal rat liver group and the steatosis group, but no effective distinction can be made between different degrees of steatosis. At the same time, mild inflammatory activity did not affect ARFI measurements.