论文部分内容阅读
[目的]探索经肝动脉加温化疗治疗肝恶性肿瘤的价值。[方法]肝恶性肿瘤61例 ,经肝动脉加温化疗168次。灌注温度为43℃～45℃、流速20ml/min～50ml/min、总量600ml～1000ml、时间30min～60min。化疗药物(5 Fu0.75g～1.0g、MMC12mg～20mg、DDP60mg～80mg)三药联用。[结果]经两次以上治疗 ,随访6～48个月 ,资料完整61例。近期有效率88.5%(CR3、PR51例、NC7例) ,术中患者均有不同程度的心窝部灼热感、全身发热及出汗等 ,术后副反应与常温法相近。[结论]通过导管将热疗与化疗相结合的方法治疗肝恶性肿瘤有肯定疗效 ,且没有严重副反应。今后需要通过大量的临床实践 ,进一步改进和完善灌注方案以提高疗效。
[Objective] To explore the value of warming hepatic malignancy by hepatic artery warming chemotherapy. [Method] 61 cases of malignant liver tumor were treated with warming hepatic artery 168 times. Perfusion temperature of 43 ℃ ~ 45 ℃, the flow rate of 20ml / min ~ 50ml / min, the total amount of 600ml ~ 1000ml, time 30min ~ 60min. Chemotherapy drugs (5 Fu0.75g ~ 1.0g, MMC12mg ~ 20mg, DDP60mg ~ 80mg) combined with three drugs. [Result] After more than two times of treatment, the patients were followed up for 6 ~ 48 months and the data were complete in 61 cases. The recent efficiency of 88.5% (CR3, PR51 cases, NC7 cases), intraoperative patients have varying degrees of heartburn, general fever and sweating, postoperative side effects and room temperature method similar. [Conclusion] The treatment of hepatic malignant tumor by the combination of hyperthermia and chemotherapy through the catheter has a certain effect, and no serious side effects. In the future, we need to further improve and perfect the perfusion plan through a large number of clinical practice to improve the curative effect.