卵巢癌是常见的妇科恶性肿瘤,其死亡率居妇科肿瘤之首。化疗是其重要的治疗手段,而随之产生的肿瘤细胞多药耐药成为治疗失败的主要原因。低氧是所有实体肿瘤的特征,缺氧诱导因子-1α(HIF-1α)是介导细胞低氧反应最关键的核转录因子,对卵巢癌多药耐药的形成起到多方面的作用,本文就近年来以HIF-1α为靶点研究卵巢癌耐药的研究进展作一综述。 Ovarian cancer is a common gynecological malignancy, the mortality rate of gynecological tumors in the first. Chemotherapy is its important treatment, and the resulting multi-drug resistance of tumor cells become the main reason for treatment failure. Hypoxia is a characteristic of all solid tumors. Hypoxia-inducible factor-1α (HIF-1α) is the most critical nuclear transcription factor that mediates cell hypoxia and plays a multifaceted role in the development of multidrug resistance in ovarian cancer. In this paper, in recent years to HIF-1α as a target to study the progress of drug-resistant ovarian cancer are reviewed.