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药物一脑电图(pharmaco-electroen-cephalography,PEEG)成为独立的学科已近二十年。最初是用常规的肉眼分析方法。事实上,Hans Berger在他的第三篇有关脑电图(EEG)的文章中就报告了一男性被试者在服用30mg可卡因20分钟后,表现为α波振幅增加,β波活动无变化以及伴有明显的行为变化。在同文中,Berger还报告EEG和行为随着东莨菪碱和吗啡剂量不同而变化的现象。因此,人们也将EEG的创始人Berger称为第一位药物脑电图研究者。由于脑电图本身的准确性、可重复性及客观性,使得药物脑电图这一学科不断发展。近十年来,随着计算机的广泛应用,严密的实验设计、数字信号分析以及统计学处理方法应用
Pharmaco-electroen-cephalography (PEEG) has been an independent discipline for nearly two decades. Initially using the conventional visual analysis. In fact, Hans Berger reported in his third article on electroencephalography (EEG) that a male subject showed an increase in a-wave amplitude and no change in beta-wave activity after taking 20 mg of cocaine for 30 mg Accompanied by significant behavioral changes. In the same article, Berger also reports that EEG and behavior vary with the dose of scopolamine and morphine. As a result, Berger, the founder of EEG, is also called the first drug EEG researcher. Due to the accuracy, repeatability and objectivity of the EEG itself, the discipline of electroencephalogram (EEG) continues to evolve. Over the past decade, with the extensive use of computers, rigorous experimental design, digital signal analysis and application of statistical processing methods