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目的研究胰岛素样生长因子Ⅰ受体(IGF-1R)在膀胱移行细胞癌中的表达及其与临床的关系。方法78例膀胱癌标本来自2000年~2002年间在我院手术治疗的膀胱移行上皮肿瘤患者,采用免疫组织化学法检测不同临床分期,病理分级患者以及初发及复发患者膀胱移行细胞癌组织的IGF-1R水平。结果在膀胱移行细胞癌中IGF-1R的表达阳性率明显升高,IGF-1R的表达与肿瘤的临床分期和病理分级以及肿瘤复发呈正相关(P<0.05)。结论IGF-1R在膀胱移行细胞癌的生长中起重要的作用,可以作为临床判断患者预后的辅助指标。
Objective To study the expression of insulin-like growth factor-1 receptor (IGF-1R) in transitional cell carcinoma of the bladder and its clinical significance. Methods 78 cases of bladder cancer specimens from patients with bladder transitional epithelial tumors treated in our hospital from 2000 to 2002 were detected by immunohistochemistry in patients with different clinical stages and pathological grading as well as primary and recurrent bladder transitional cell carcinoma of IGF -1R level. Results The positive rate of IGF-1R expression in transitional cell carcinoma of the bladder was significantly increased. The expression of IGF-1R was positively correlated with the clinical stage and pathological grade of tumor and tumor recurrence (P <0.05). Conclusion IGF-1R plays an important role in the growth of transitional cell carcinoma of the bladder and can be used as an auxiliary index to judge the prognosis of patients.