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目的探讨不稳定型心绞痛(UA)患者阿司匹林和氯吡格雷治疗前后的血小板活化状态。方法住院的UA 80例,随机分成A、B两组。检测住院当日、用药24 h后及用药7 d后CD62P、TXB2及PAGM。结果不稳定型心绞痛CD62P、TXB2和PAGM治疗前无统计学意义;治疗后B组与A组比较有统计学意义。结论在UA患者中,血小板活化起到重要作用,氯吡格雷联合阿司匹林较单用阿司匹林组抑制血小板聚集起效快;两组对抑制血小板聚集都有效,但联合用药组抑制血小板聚集作用更强。
Objective To investigate the platelet activation in patients with unstable angina pectoris (UA) before and after aspirin and clopidogrel treatment. Methods 80 hospitalized UA patients were randomly divided into A and B groups. On the day of hospitalization, CD62P, TXB2 and PAGM were measured 24 h after treatment and 7 d after treatment. Results The unstable angina pectoris CD62P, TXB2 and PAGM had no statistical significance before treatment; after treatment, B group and A group were statistically significant. Conclusion Platelet activation plays an important role in UA patients. Clopidogrel combined with aspirin is more effective in inhibiting platelet aggregation than aspirin alone. Both of the two groups are effective in inhibiting platelet aggregation, but the combined treatment group is more effective in inhibiting platelet aggregation.